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Meeting 2: Committee to Review Dietary Reference Intakes for Vitamin D and Calcium


Event Date: August 04, 2009 - August 05, 2009


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The second committee meeting was held August 4-5, 2009 in Washington, DC and included an Information-Gathering Workshop on August 4, 2009.  The agenda for this workshop is below, along with the PowerPoint presentations that were used by the speakers during the workshop.

Please note, online presentations from this meeting are subject to copyright protection. Permission from the speaker is required prior to any copying, reproducing, or rebroadcasting any portion of the speaker's presentations. Additional copyright and legal policies of The National Academies can be read in the National Academies Legal Statement.

Written comments can be submitted electronically at any time to: vitD-calcium@nas.edu. Please note that any comments you submit to the committee through this website or otherwise, including your name and identifying information, will not be kept confidential and will be included in a Public Access File. The National Academies shall be authorized to use any such comments or submissions in accordance with the National Academies’ Terms of Use Statement

Questions may be forwarded to: vitD-calcium@nas.edu
INFORMATION-GATHERING WORKSHOP AGENDA

The Keck Center, Room 100
500 Fifth Street, NW
Washington, DC 20001
August 4, 2009
8:00 am – 5:00 pm

7:30 – 8:00     Registration and Check-in

8:00 – 8:10     Welcome and Overview of Committee Process & Open Session 
   Catharine Ross, Chair

SESSION 1:  Agency for Healthcare Research and Quality (ARHQ)
8:10 – 8:35        Development of AHRQ Review: Relationships of Vitamin D and Calcium Intakes to Nutrient Status Indicators and Health Outcomes (released June 2009)
(View PowerPoint) (Listen to Audio)
   Joseph Lau, Tufts University

 8:35 – 9:15       Committee Discussion with Dr. Lau and Tufts University Staff   (Listen to Audio)

SESSION 2: Analytical Issues: Vitamin D
9:15 – 9:35        Comparison of Methods   (View PowerPoint) (Listen to Audio)
   Karen Phinney, National Institute of Standards and Technology (NIST)

9:35 – 9:50        Analytical Issues: National Health and Nutrition Examination Survey (NHANES)    (View PowerPoint) (Listen to Audio)
   Clifford Johnson, National Center for Health Statistics (NCHS)

 9:50 – 10:15      Joint Discussion with Committee   (Listen to Audio)

10:15 – 10:30    Break

SESSION 3: Biomarkers
10:30 – 10:50    Biomarkers: General Principles for Definition and Utility as Measures of Exposure or Functional Outcome   (View PowerPoint) (Listen to Audio)
   Roberta Ness, University of Texas Health Science Center and IOM Committee on Biomarkers as Surrogate 
   Endpoints of Chronic Disease Risk

10:50 – 11:00    Committee Discussion with Dr. Ness   (Listen to Audio)

SESSION 4: Vascular Changes
11:00 – 11:15    Vascular Changes Associated with Vitamin D and Calcium   (View PowerPoint) (Listen to Audio)
   Keith Hruska, Washington University, St. Louis 

11:15 – 11:35    Committee Discussion with Dr. Hruska   (Listen to Audio)                

SESSION 5: Chronic Disease Endpoints: Observational Data versus Randomized Clinical Trials
11:35 – 11:50          Edward Giovannucci, Harvard University   
                                   (View PowerPoint) (Listen to Audio)

11:50 – 12:05          Barry Kramer, National Institutes of Health (NIH)   
                                  
(View PowerPoint) (Listen to Audio)

12:05 – 12:30    Joint Discussion with Committee   (Listen to Audio)

12:30 – 1:30      LUNCH

SESSION 6: Perspectives on Evaluating Data for Determining Reference Values for Vitamin D and Calcium
Perspectives from 1995-96 DRI Committee
1:30 – 1:40              Stephanie Atkinson, McMaster University: Perinatal   
                                 
(View PowerPoint) (Listen to Audio)
1:40 – 1:50              Connie Weaver, Purdue University: Adolescents   
                                 
(View PowerPoint) (Listen to Audio)
1:50 – 2:00              Bess Dawson-Hughes, Tufts University: Elderly   
                                 
(View PowerPoint) (Listen to Audio)
2:00 – 2:10              Robert Heaney, Creighton University: Calcium and Calcium/Vitamin D Interactions   
                                 
(View PowerPoint) (Listen to Audio)
2:10 – 2:20              Michael Holick, Boston University: Dietary vs. Solar Sources   
                                  (View PowerPoint) (Listen to Audio)

2:20 – 2:45        Joint Discussion with Committee   (Listen to Audio)

2:45 – 3:00        Break

Perspectives from Other Vitamin D and Calcium Experts
3:00 – 3:10              Bruce Hollis, Medical University of South Carolina: Assay Methodologies  
                                  (View PowerPoint) (Listen to Audio)
3:10 – 3:20              Cedric Garland, University of California—San Diego: Cancer   
                                  (View PowerPoint) (Listen to Audio)
3:20 – 3:30              Roger Bouillon, Katholieke Universiteit Leuven: Immune Function   
                                  (View PowerPoint) (Listen to Audio)
3:30 – 3:40              Reinhold Vieth, University of Toronto: Safety of Vitamin D  
                                  
(View PowerPoint) (Listen to Audio)

3:40 – 4:00        Joint Discussion with Committee (Listen to Audio)

4:00 – 4:15        Break 

SESSION 7: PUBLIC COMMENTS – 5 minutes each (required pre-registration)
(Listen to Audio)
GrassrootsHealth (Carole Baggerly) 
University of California—Riverside & Vitamin D Workshop (Tony Norman) (View PowerPoint)
University of California—San Diego (Edward Gorham) (View PowerPoint)
Sunlight, Nutrition, and Health Research Center (William Grant) (View PowerPoint)
St. Luke's-Roosevelt Hospital Center (Linda Linday)
Autoimmunity Research Foundation (Amy Proal) (View PowerPoint)
Weill Cornell Medical College (Paul Albert) (View PowerPoint)
The Mount Sinai Hospital and Mount Sinai School of Medicine (Laurie Tansman)
International Diary Foods Association (Michelle Matto)
National Osteoporosis Foundation (Roberta Biegel)
National Dairy Council (Jill Nicholls)
Lallemand/American Yeast (James Kopp, Sr.) (View PowerPoint)

5:00                  Workshop Adjourned

This meeting is being held to gather information to help the committee conduct its study. This committee will examine the information and material obtained during this, and other public meetings, in an effort to inform its work. Although opinions may be stated and lively discussion may ensue, no conclusions are being drawn at this time; no recommendations will be made. In fact, the committee will deliberate thoroughly before writing its draft report. Moreover, once the draft report is written, it must go through a rigorous review by experts who are anonymous to the committee, and the committee then must respond to this review with appropriate revisions that adequately satisfy the Academy's Report Review committee and the chair of the NRC before it is considered an NRC report. Therefore, observers who draw conclusions about the committee's work based on today's discussions will be doing so prematurely.

Furthermore, individual committee members often engage in discussion and questioning for the specific purpose of probing an issue and sharpening an argument. The comments of any given committee member may not necessarily reflect the position he or she may actually hold on the subject under discussion, to say nothing of that person's future position as it may evolve in the course of the project. Any inference about an individual’s position regarding findings or recommendations in the final report are therefore also premature.



Resources & Links
Agenda Draft: Vitamin D and Calcium August 4, 2009 Open Public Workshop
Vitamin D and Calcium - A Systematic Review of Health Outcomes
Joseph Lau
Agency for Healthcare Research and Quality Committee Discussion
Methods Development and Standard Reference Materials for 25(OH)D
Karen Phinney
Vitamin D Biomarker Analytical Issues in NHANES
Clifford Johnson
Analytical Issues - Vitamin D Committee Discussion
Biomarkers - What Are the Methodological Issues
Roberta Ness
Biomarkers Committee Discussion
Vascular Physiology - Changes Associated with Vitamin D
Keith Hruska
Vascular Changes Committee Discussion
Observational Studies vs. Randomized Controlled Trials
Edward Giovannucci
Weighing Scientific Evidence
Barry Kramer
Chronic Disease Endpoints Committee Discussion
Vitamin D and Calcium - Perinatal and Young Children
Stephanie Atkinson
Evaluating Data for Setting Calcium and Vitamin D Requirements in Adolescents
Connie Weaver
Vitamin D - Falls and Fractures in Men and Women Aged 65 Years and Older
Bess Dawson-Hughes
Vitamin D-Calcium Interactions
Robert Heaney
The D-lightful Vitamin for Health
Michael Holick
Perspectives from 1995-66 DRI Committee Discussion
Assays for the Determination of 25(OH)D
Bruce Hollis
Vitamin D and Cancer
Cedric Garland
Vitamin D and its Role in the Immune System
Roger Bouillon
Safety of Vitamin D
Reinhold Vieth
Perspectives from Other Vitamin D and Calcium Experts Discussion
Public Comments
Anthony W. Norman
Edward D. Gorham
William B. Grant
Paul Albert
Amy Proal
James T. Kopp, Sr.